9AZQ

INF2 at the Barbed End of F-Actin with Incoming Actin

External Resource: Annotation

Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Protein Modification Annotation

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, I	Actin, alpha skeletal muscle	cytoskeletal protein binding titin binding protein binding binding cation binding ion binding calcium ion binding metal ion binding small molecule binding protein domain specific binding hydrolase activity catalytic activity troponin I binding cytoskeletal motor activator activity cytoskeletal protein binding titin binding protein binding binding cation binding ion binding calcium ion binding metal ion binding small molecule binding protein domain specific binding hydrolase activity catalytic activity troponin I binding cytoskeletal motor activator activity cytoskeletal motor regulator activity molecular function activator activity molecular function regulator activity magnesium ion binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding myosin heavy chain binding myosin binding tropomyosin binding calcium-dependent protein binding identical protein binding actin monomer binding actin binding	developmental process mesenchyme migration multicellular organismal process mesenchyme morphogenesis animal organ development mesenchyme development tissue development tissue morphogenesis anatomical structure morphogenesis tissue migration anatomical structure development animal organ morphogenesis myotube cell development skeletal muscle fiber development developmental process mesenchyme migration multicellular organismal process mesenchyme morphogenesis animal organ development mesenchyme development tissue development tissue morphogenesis anatomical structure morphogenesis tissue migration anatomical structure development animal organ morphogenesis myotube cell development skeletal muscle fiber development cellular developmental process skeletal muscle tissue development cell development muscle cell differentiation myotube differentiation muscle structure development skeletal muscle organ development muscle cell development cell differentiation cellular process muscle tissue development muscle organ development striated muscle cell differentiation regulation of cellular process cellular biosynthetic process positive regulation of biological process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process organic substance metabolic process positive regulation of biosynthetic process organic substance biosynthetic process positive regulation of macromolecule metabolic process positive regulation of cellular process regulation of biosynthetic process regulation of biological process cellular metabolic process biological regulation regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process positive regulation of gene expression regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process positive regulation of cellular biosynthetic process cellular component assembly involved in morphogenesis non-membrane-bounded organelle assembly skeletal myofibril assembly cellular component organization cellular component biogenesis striated muscle cell development cellular anatomical entity morphogenesis cellular component assembly actin filament-based process cellular component organization or biogenesis skeletal muscle thin filament assembly actin cytoskeleton organization actomyosin structure organization organelle assembly actin filament organization organelle organization myofibril assembly anatomical structure formation involved in morphogenesis supramolecular fiber organization cytoskeleton organization protein polymerization actin polymerization or depolymerization actin filament polymerization protein-containing complex organization protein-containing complex assembly actin filament bundle organization actin filament bundle assembly	intracellular anatomical structure skeletal muscle myofibril cellular anatomical entity intracellular organelle organelle intracellular non-membrane-bounded organelle contractile muscle fiber cytoplasm supramolecular fiber myofibril supramolecular polymer supramolecular complex non-membrane-bounded organelle cell projection intracellular anatomical structure skeletal muscle myofibril cellular anatomical entity intracellular organelle organelle intracellular non-membrane-bounded organelle contractile muscle fiber cytoplasm supramolecular fiber myofibril supramolecular polymer supramolecular complex non-membrane-bounded organelle cell projection cell leading edge plasma membrane bounded cell projection lamellipodium cytoskeleton actin filament bundle actin cytoskeleton actomyosin stress fiber contractile actin filament bundle polymeric cytoskeletal fiber actin filament protein-containing complex filamentous actin cell body striated muscle thin filament myofilament sarcomere actin-based cell projection filopodium
G	Inverted formin-2	small GTPase binding protein binding binding enzyme binding GTPase binding cytoskeletal protein binding actin binding	protein polymerization actin polymerization or depolymerization actin filament polymerization actin cytoskeleton organization protein-containing complex organization actin filament organization cellular component organization cellular component biogenesis organelle organization cellular component assembly protein-containing complex assembly actin filament-based process cellular process cellular component organization or biogenesis protein polymerization actin polymerization or depolymerization actin filament polymerization actin cytoskeleton organization protein-containing complex organization actin filament organization cellular component organization cellular component biogenesis organelle organization cellular component assembly protein-containing complex assembly actin filament-based process cellular process cellular component organization or biogenesis supramolecular fiber organization cytoskeleton organization developmental process regulation of biological process regulation of cellular component organization regulation of cellular process regulation of developmental process organelle fission biological regulation mitochondrial fission regulation of organelle organization anatomical structure morphogenesis regulation of mitochondrial fission regulation of mitochondrion organization anatomical structure development regulation of anatomical structure morphogenesis mitochondrion organization	intracellular anatomical structure perinuclear region of cytoplasm cytoplasm cellular anatomical entity polymeric cytoskeletal fiber actin filament actin cytoskeleton intracellular organelle cytoskeleton organelle intracellular non-membrane-bounded organelle supramolecular fiber supramolecular polymer supramolecular complex intracellular anatomical structure perinuclear region of cytoplasm cytoplasm cellular anatomical entity polymeric cytoskeletal fiber actin filament actin cytoskeleton intracellular organelle cytoskeleton organelle intracellular non-membrane-bounded organelle supramolecular fiber supramolecular polymer supramolecular complex non-membrane-bounded organelle
H	Inverted formin-2	small GTPase binding protein binding binding enzyme binding GTPase binding cytoskeletal protein binding actin binding	protein polymerization actin polymerization or depolymerization actin filament polymerization actin cytoskeleton organization protein-containing complex organization actin filament organization cellular component organization cellular component biogenesis organelle organization cellular component assembly protein-containing complex assembly actin filament-based process cellular process cellular component organization or biogenesis protein polymerization actin polymerization or depolymerization actin filament polymerization actin cytoskeleton organization protein-containing complex organization actin filament organization cellular component organization cellular component biogenesis organelle organization cellular component assembly protein-containing complex assembly actin filament-based process cellular process cellular component organization or biogenesis supramolecular fiber organization cytoskeleton organization developmental process regulation of biological process regulation of cellular component organization regulation of cellular process regulation of developmental process organelle fission biological regulation mitochondrial fission regulation of organelle organization anatomical structure morphogenesis regulation of mitochondrial fission regulation of mitochondrion organization anatomical structure development regulation of anatomical structure morphogenesis mitochondrion organization	intracellular anatomical structure perinuclear region of cytoplasm cytoplasm cellular anatomical entity polymeric cytoskeletal fiber actin filament actin cytoskeleton intracellular organelle cytoskeleton organelle intracellular non-membrane-bounded organelle supramolecular fiber supramolecular polymer supramolecular complex intracellular anatomical structure perinuclear region of cytoplasm cytoplasm cellular anatomical entity polymeric cytoskeletal fiber actin filament actin cytoskeleton intracellular organelle cytoskeleton organelle intracellular non-membrane-bounded organelle supramolecular fiber supramolecular polymer supramolecular complex non-membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, I	IPR020902	Actin/actin-like conserved site	Conserved Site
A, B, C, D, E A, B, C, D, E, F, I	IPR043129	ATPase, nucleotide binding domain	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, I	IPR004001	Actin, conserved site	Conserved Site
A, B, C, D, E A, B, C, D, E, F, I	IPR004000	Actin family	Family
G	IPR042201	Formin, FH2 domain superfamily	Homologous Superfamily
G	IPR010472	Formin, FH3 domain	Domain
G	IPR010473	Formin, GTPase-binding domain	Domain
G	IPR014768	Rho GTPase-binding/formin homology 3 (GBD/FH3) domain	Domain
G	IPR016024	Armadillo-type fold	Homologous Superfamily
G	IPR015425	Formin, FH2 domain	Domain
G	IPR027649	Inverted formin-2	Family
G	IPR011989	Armadillo-like helical	Homologous Superfamily
G	IPR003124	WH2 domain	Domain
H	IPR042201	Formin, FH2 domain superfamily	Homologous Superfamily
H	IPR010472	Formin, FH3 domain	Domain
H	IPR010473	Formin, GTPase-binding domain	Domain
H	IPR014768	Rho GTPase-binding/formin homology 3 (GBD/FH3) domain	Domain
H	IPR016024	Armadillo-type fold	Homologous Superfamily
H	IPR015425	Formin, FH2 domain	Domain
H	IPR027649	Inverted formin-2	Family
H	IPR011989	Armadillo-like helical	Homologous Superfamily
H	IPR003124	WH2 domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
G	Pharos: Q27J81	Charcot-Marie-Tooth disease Charcot-Marie-Tooth disease dominant intermediate E focal segmental glomerulosclerosis 5 peripheral neuropathy focal segmental glomerulosclerosis atypical teratoid rhabdoid tumor chronic obstructive pulmonary disease Focal glomerulosclerosis lung adenocarcinoma neurodegenerative disease diabetes mellitus intellectual disability medulloblastoma osteosarcoma psoriasis Charcot-Marie-Tooth disease Charcot-Marie-Tooth disease dominant intermediate E focal segmental glomerulosclerosis 5 peripheral neuropathy focal segmental glomerulosclerosis atypical teratoid rhabdoid tumor chronic obstructive pulmonary disease Focal glomerulosclerosis lung adenocarcinoma neurodegenerative disease diabetes mellitus intellectual disability medulloblastoma osteosarcoma psoriasis endometrial carcinoma large cell medulloblastoma motor peripheral neuropathy peripheral nervous system disease
H	Pharos: Q27J81	Charcot-Marie-Tooth disease Charcot-Marie-Tooth disease dominant intermediate E focal segmental glomerulosclerosis 5 peripheral neuropathy focal segmental glomerulosclerosis atypical teratoid rhabdoid tumor chronic obstructive pulmonary disease Focal glomerulosclerosis lung adenocarcinoma neurodegenerative disease diabetes mellitus intellectual disability medulloblastoma osteosarcoma psoriasis Charcot-Marie-Tooth disease Charcot-Marie-Tooth disease dominant intermediate E focal segmental glomerulosclerosis 5 peripheral neuropathy focal segmental glomerulosclerosis atypical teratoid rhabdoid tumor chronic obstructive pulmonary disease Focal glomerulosclerosis lung adenocarcinoma neurodegenerative disease diabetes mellitus intellectual disability medulloblastoma osteosarcoma psoriasis endometrial carcinoma large cell medulloblastoma motor peripheral neuropathy peripheral nervous system disease

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
A, B, C, D, E A, B, C, D, E, F, I	HIC	Parent Component: HIS RESID: AA0317 PSI-MOD : 1'-methyl-L-histidine MOD:00322