Annotations: 8U3Z

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, D [auth F]	Tubulin alpha-1B chain	RNA binding double-stranded RNA binding binding organic cyclic compound binding nucleic acid binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding RNA binding double-stranded RNA binding binding organic cyclic compound binding nucleic acid binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding structural constituent of cytoskeleton structural molecule activity ubiquitin protein ligase binding protein binding ubiquitin-like protein ligase binding enzyme binding pyrophosphatase activity GTPase activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity	cellular process cell cycle mitotic cell cycle cell division cellular response to stimulus response to organic substance response to stimulus response to cytokine response to interleukin-4 cellular response to chemical stimulus response to chemical cellular response to cytokine stimulus cellular response to interleukin-4 cellular response to organic substance cellular process cell cycle mitotic cell cycle cell division cellular response to stimulus response to organic substance response to stimulus response to cytokine response to interleukin-4 cellular response to chemical stimulus response to chemical cellular response to cytokine stimulus cellular response to interleukin-4 cellular response to organic substance localization cellular localization transport establishment of localization in cell cytoskeleton-dependent intracellular transport intracellular transport establishment of localization cellular component organization organelle organization microtubule cytoskeleton organization microtubule-based process cellular component organization or biogenesis cytoskeleton organization	intracellular anatomical structure cytoplasm cellular anatomical entity intracellular organelle cytoskeleton organelle intracellular non-membrane-bounded organelle microtubule cytoskeleton non-membrane-bounded organelle polymeric cytoskeletal fiber cytoplasmic microtubule supramolecular fiber microtubule supramolecular polymer intracellular anatomical structure cytoplasm cellular anatomical entity intracellular organelle cytoskeleton organelle intracellular non-membrane-bounded organelle microtubule cytoskeleton non-membrane-bounded organelle polymeric cytoskeletal fiber cytoplasmic microtubule supramolecular fiber microtubule supramolecular polymer supramolecular complex
B, C [auth E]	Tubulin beta chain	protein binding binding protein domain specific binding GTPase activating protein binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding organic cyclic compound binding purine nucleotide binding protein binding binding protein domain specific binding GTPase activating protein binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding organic cyclic compound binding purine nucleotide binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding protein-containing complex binding structural constituent of cytoskeleton structural molecule activity ubiquitin protein ligase binding ubiquitin-like protein ligase binding enzyme binding MHC class I protein binding signaling receptor binding MHC protein binding cation binding metal ion binding pyrophosphatase activity GTPase activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity	cellular process cell cycle mitotic cell cycle cell division regulation of biological process regulation of cellular component organization regulation of cellular process biological regulation cellular component organization regulation of synapse organization cell junction organization regulation of synapse structure or activity synapse organization cellular component organization or biogenesis cellular process cell cycle mitotic cell cycle cell division regulation of biological process regulation of cellular component organization regulation of cellular process biological regulation cellular component organization regulation of synapse organization cell junction organization regulation of synapse structure or activity synapse organization cellular component organization or biogenesis regulation of biological quality organelle assembly non-membrane-bounded organelle assembly microtubule cytoskeleton organization spindle assembly cellular component biogenesis organelle organization cellular component assembly microtubule-based process cytoskeleton organization chromosome segregation spindle organization cell cycle process lymphocyte mediated immunity biological process involved in interspecies interaction between organisms response to stimulus immune response response to other organism defense response defense response to symbiont response to external stimulus leukocyte mediated cytotoxicity response to biotic stimulus immune effector process immune system process defense response to other organism response to stress natural killer cell mediated cytotoxicity innate immune response leukocyte mediated immunity response to external biotic stimulus natural killer cell mediated immunity cell killing localization cellular localization transport establishment of localization in cell cytoskeleton-dependent intracellular transport intracellular transport establishment of localization developmental process epithelium development cellular developmental process tissue development epithelial cell differentiation cell differentiation anatomical structure development neuroepithelial cell differentiation odontoblast differentiation columnar/cuboidal epithelial cell differentiation	extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space cellular anatomical entity vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol membrane microdomain extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space cellular anatomical entity vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol membrane microdomain membrane raft membrane lytic vacuole intracellular vesicle membrane-enclosed lumen cytoplasmic vesicle lumen vacuolar lumen endomembrane system intracellular organelle lumen intracellular organelle cytoplasmic vesicle lysosome vesicle lumen azurophil granule vacuole intracellular membrane-bounded organelle secretory granule lumen azurophil granule lumen organelle lumen secretory granule primary lysosome secretory vesicle mitotic spindle cytoskeleton spindle intracellular non-membrane-bounded organelle microtubule cytoskeleton non-membrane-bounded organelle protein-containing complex cytoplasmic ribonucleoprotein granule supramolecular complex ribonucleoprotein granule intercellular bridge nucleus organelle envelope lumen organelle envelope nuclear envelope lumen nuclear envelope cell body polymeric cytoskeletal fiber supramolecular fiber microtubule supramolecular polymer
E [auth N]	Tubulin polyglutamylase TTLL6	acid-amino acid ligase activity tubulin-glutamic acid ligase activity catalytic activity, acting on a protein protein-glutamic acid ligase activity catalytic activity ligase activity, forming carbon-nitrogen bonds ligase activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding acid-amino acid ligase activity tubulin-glutamic acid ligase activity catalytic activity, acting on a protein protein-glutamic acid ligase activity catalytic activity ligase activity, forming carbon-nitrogen bonds ligase activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding cytoskeletal protein binding protein binding tubulin binding cation binding metal ion binding	cellular component organization microtubule bundle formation organelle organization microtubule cytoskeleton organization cellular process microtubule-based process cellular component organization or biogenesis cytoskeleton organization microtubule severing organonitrogen compound metabolic process protein polyglutamylation primary metabolic process organic substance metabolic process peptidyl-glutamic acid modification cellular component organization microtubule bundle formation organelle organization microtubule cytoskeleton organization cellular process microtubule-based process cellular component organization or biogenesis cytoskeleton organization microtubule severing organonitrogen compound metabolic process protein polyglutamylation primary metabolic process organic substance metabolic process peptidyl-glutamic acid modification macromolecule modification peptidyl-amino acid modification metabolic process protein metabolic process macromolecule metabolic process protein modification process regulation of biological process regulation of cellular process regulation of cell motility biological regulation regulation of microtubule-based process regulation of microtubule-based movement cilium movement involved in cell motility regulation of cilium-dependent cell motility cilium or flagellum-dependent cell motility regulation of cilium movement cilium-dependent cell motility regulation of cilium beat frequency regulation of locomotion regulation of cilium beat frequency involved in ciliary motility microtubule-based movement regulation of biological quality regulation of cilium movement involved in cell motility cilium movement cell motility locomotion positive regulation of biological process positive regulation of cilium movement positive regulation of cellular process	membrane-bounded organelle cell projection organelle cilium cellular anatomical entity plasma membrane bounded cell projection intracellular anatomical structure cytoplasm intracellular organelle ciliary basal body microtubule organizing center cytoskeleton intracellular non-membrane-bounded organelle microtubule cytoskeleton membrane-bounded organelle cell projection organelle cilium cellular anatomical entity plasma membrane bounded cell projection intracellular anatomical structure cytoplasm intracellular organelle ciliary basal body microtubule organizing center cytoskeleton intracellular non-membrane-bounded organelle microtubule cytoskeleton non-membrane-bounded organelle non-motile cilium 9+0 non-motile cilium polymeric cytoskeletal fiber supramolecular fiber microtubule supramolecular polymer supramolecular complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, D [auth F]	IPR008280	Tubulin/FtsZ, C-terminal	Homologous Superfamily
A, D [auth F]	IPR017975	Tubulin, conserved site	Conserved Site
A, D [auth F]	IPR023123	Tubulin, C-terminal	Homologous Superfamily
A, D [auth F]	IPR018316	Tubulin/FtsZ, 2-layer sandwich domain	Domain
A, D [auth F]	IPR003008	Tubulin/FtsZ, GTPase domain	Domain
A, D [auth F]	IPR037103	Tubulin/FtsZ-like, C-terminal domain	Homologous Superfamily
A, D [auth F]	IPR002452	Alpha tubulin	Family
A, D [auth F]	IPR000217	Tubulin	Family
A, D [auth F]	IPR036525	Tubulin/FtsZ, GTPase domain superfamily	Homologous Superfamily
B, C [auth E]	IPR008280	Tubulin/FtsZ, C-terminal	Homologous Superfamily
B, C [auth E]	IPR017975	Tubulin, conserved site	Conserved Site
B, C [auth E]	IPR023123	Tubulin, C-terminal	Homologous Superfamily
B, C [auth E]	IPR002453	Beta tubulin	Family
B, C [auth E]	IPR013838	Beta tubulin, autoregulation binding site	Binding Site
B, C [auth E]	IPR018316	Tubulin/FtsZ, 2-layer sandwich domain	Domain
B, C [auth E]	IPR003008	Tubulin/FtsZ, GTPase domain	Domain
B, C [auth E]	IPR037103	Tubulin/FtsZ-like, C-terminal domain	Homologous Superfamily
B, C [auth E]	IPR000217	Tubulin	Family
B, C [auth E]	IPR036525	Tubulin/FtsZ, GTPase domain superfamily	Homologous Superfamily
E [auth N]	IPR004344	Tubulin-tyrosine ligase/Tubulin polyglutamylase	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, D [auth F]	Pharos: P68363	osteoporosis anogenital human papillomavirus infection breast cancer Osteoporosis, Senile attention deficit hyperactivity disorder, inattentive type bipolar disorder
B, C [auth E]	Pharos: P07437	complex cortical dysplasia with other brain malformations 6 non-small cell lung carcinoma ovarian cancer multiple benign circumferential skin creases on limbs 1 fallopian tube carcinoma gestational trophoblastic neoplasm Hodgkin's granuloma primitive neuroectodermal tumor Kaposi's sarcoma psoriatic arthritis actinic keratosis large cell medulloblastoma Sjogren syndrome lung cancer breast cancer complex cortical dysplasia with other brain malformations 6 non-small cell lung carcinoma ovarian cancer multiple benign circumferential skin creases on limbs 1 fallopian tube carcinoma gestational trophoblastic neoplasm Hodgkin's granuloma primitive neuroectodermal tumor Kaposi's sarcoma psoriatic arthritis actinic keratosis large cell medulloblastoma Sjogren syndrome lung cancer breast cancer malignant colon neoplasm chronic obstructive pulmonary disease cutaneous lupus erythematosus Duchenne muscular dystrophy neuroblastoma ocular hypertension Hashimoto thyroiditis pancreatic ductal adenocarcinoma Hodgkins lymphoma prostate cancer kidney Wilms tumor rhabdomyosarcoma acute lymphoblastic leukemia liposarcoma testicular cancer atypical teratoid rhabdoid tumor lung carcinoma breast carcinoma malignant glioma medulloblastoma colorectal cancer mycosis fungoides endogenous depression gastric cancer open-angle glaucoma plasma cell myeloma hypertensive disorder prostate carcinoma Langerhans cell histiocytosis age-related macular degeneration lung adenocarcinoma transitional cell carcinoma autism spectrum disorder lymphoplasmacytic lymphoma Burkitt lymphoma cervical cancer multiple benign circumferential skin creases on limbs nasopharyngeal carcinoma